059 THERAPEUTIC DRUG MONITORING BY LC-MS/MS
نویسندگان
چکیده
منابع مشابه
Standardization of LC-MS for therapeutic drug monitoring of tacrolimus.
BACKGROUND LC-MS is increasingly used for therapeutic drug monitoring of tacrolimus. A recent summary from an international proficiency-testing scheme demonstrated that the mass spectrometry respondents were the largest method group. However, these methods lack standardization, which may explain the relatively poor interlaboratory agreement for such methods. This study aimed to provide one path...
متن کاملCurrent role of LC-MS in therapeutic drug monitoring.
The role of liquid chromatography coupled with mass spectrometry (LC-MS) techniques in routine therapeutic drug monitoring activity is becoming increasingly important. This paper reviews LC-MS methods published in the last few years for certain classes of drugs subject to therapeutic drug monitoring: immunosuppressants, antifungal drugs, antiretroviral drugs, antidepressants and antipsychotics....
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A simple, rapid and sensitive HPLC method for the quantification of quinidine in human plasma has been developed and validated. Quinidine was separated on a C18 column under isocratic conditions using a mobile phase of 85:15 (v/v) 0.2% formic acid and acetonitrile. In these chromatographic conditions, the retention time of quinidine was 1.2 min and the overall time of one analysis was 1.6 min. ...
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Therapeutic molecules possessing distinct pharmacokinetic variation, narrow therapeutic index and concentration dependent therapeutic/adverse effects demand constant monitoring. The current methods for blood sampling are invasive and possess low patient compliance. Human skin, selective and effective membrane to chemical permeation, offers an alternative route for the extraction of endogenous m...
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ژورنال
عنوان ژورنال: Indian Journal of Transplantation
سال: 2011
ISSN: 2212-0017
DOI: 10.1016/s2212-0017(11)60179-2